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Csf2rbtm1Cgb
Targeted Allele Detail
Nomenclature
Symbol: Csf2rbtm1Cgb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, C Glenn Begley
MGI ID: MGI:2181245
Synonyms: Beta-c-, Betac-, GM-CSFR-
Gene: Csf2rb  Location: Chr15:78325990-78351000 bp, + strand  Genetic Position: Chr15, 37.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29737
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 7 was disrupted by the insertion of a neomycin selection cassette that introduced stop codons into all three reading frames. A binding assay of homozygous bone marrow cells showed that high affinity binding of the colony stimulating factor was ablated. Binding of interleukin 3 was unaffected in cells isolated from mutant mice, indicating that the homologous interleukin 3 receptor was not affected by the targeting event. (J:29737)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csf2rb Mutation:  10 strains or lines available
References
Original:  J:29737 Robb L, et al., Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9565-9
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory