About   Help   FAQ
Targeted Allele Detail
Symbol: Tnfrsf11btm1Khs
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, Kanji Higashio
MGI ID: MGI:2181227
Synonyms: OCIF/OPG (-), OPG (-)
Gene: Tnfrsf11b  Location: Chr15:54250619-54278484 bp, - strand  Genetic Position: Chr15, 21.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:48325
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by insertion of a 1.3 kb PGK-neo cassette into exon 2 via homologous recombination. The insertion results in disruption of the cysteine-rich domains, which are involved in the biological activity of the protein. Homozygous mutant animals lacked gene transcription and protein product as determined by Northern and Western blot analyses. (J:48325)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11b Mutation:  17 strains or lines available
Original:  J:48325 Mizuno A, et al., Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun. 1998 Jun 29;247(3):610-5
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory