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Targeted Allele Detail
Symbol: Csf1rtm1Ers
Name: colony stimulating factor 1 receptor; targeted mutation 1, E Richard Stanley
MGI ID: MGI:2181194
Synonyms: Csf1r-
Gene: Csf1r  Location: Chr18:61105572-61131134 bp, + strand  Genetic Position: Chr18, 34.41 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:73663
Parent Cell Line:  ESVJ-1182 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was disrupted by the insertion of an in-frame cassette containing a humanized green fluorescent protein sequence and a neomycin resistance gene. While annulment of the allele in mutant mice was indicated by Western blot analysis of bone-marrow derived macrophages, expression of the green fluorescent protein could not be detected by fluorescence microscopy or flow cytometry. (J:73663)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf1r Mutation:  28 strains or lines available
Original:  J:73663 Dai XM, et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002 Jan 1;99(1):111-20
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory