About   Help   FAQ
Csf1rtm1Ers
Targeted Allele Detail
Nomenclature
Symbol: Csf1rtm1Ers
Name: colony stimulating factor 1 receptor; targeted mutation 1, E Richard Stanley
MGI ID: MGI:2181194
Synonyms: Csf1r-
Gene: Csf1r  Location: Chr18:61105572-61131134 bp, + strand  Genetic Position: Chr18, 34.41 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73663
Parent Cell Line:  ESVJ-1182 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 3 was disrupted by the insertion of an in-frame cassette containing a humanized green fluorescent protein sequence and a neomycin resistance gene. While annulment of the allele in mutant mice was indicated by Western blot analysis of bone-marrow derived macrophages, expression of the green fluorescent protein could not be detected by fluorescence microscopy or flow cytometry. (J:73663)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf1r Mutation:  8 strains or lines available
References
Original:  J:73663 Dai XM, et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002 Jan 1;99(1):111-20
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory