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Bcar1tm1Hhi
Targeted Allele Detail
Nomenclature
Symbol: Bcar1tm1Hhi
Name: breast cancer anti-estrogen resistance 1; targeted mutation 1, Hisamaru Hirai
MGI ID: MGI:2181166
Synonyms: Cas-deficient
Gene: Bcar1  Location: Chr8:111710485-111743849 bp, - strand  Genetic Position: Chr8, 57.98 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48967
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette disrupts exon 2, which encodes the SH3 domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. (J:48967, J:138258)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcar1 Mutation:  11 strains or lines available
References
Original:  J:48967 Honda H, et al., Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas [see comments]. Nat Genet. 1998 Aug;19(4):361-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory