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Targeted Allele Detail
Symbol: Itgb4tm1Fgg
Name: integrin beta 4; targeted mutation 1, Filippo G Giancotti
MGI ID: MGI:2181069
Synonyms: Beta4TL
Gene: Itgb4  Location: Chr11:115974725-116008412 bp, + strand  Genetic Position: Chr11, 80.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:48924
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA cassette containing a stop codon, a SV40 polyadenylation site, and a neomycin resistance gene was inserted immediately downstream of the exon encoding the transmembrane domain (upstream of sequence encoding the cytoplasmic domain). Expression analyses showed the presence of truncated transcript and protein in mutant mice. While Northern blot analysis detected increased levels of mutant transcript, Western blot analysis showed protein levels to be comprable to wild-type. FACS analysis confirmed that mutant protein was correctly expressed on the cell surface. (J:48924)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:  81 strains or lines available
Original:  J:48924 Murgia C, et al., Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 1998 Jul 15;17(14):3940-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory