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Cnr2tm1Zim
Targeted Allele Detail
Nomenclature
Symbol: Cnr2tm1Zim
Name: cannabinoid receptor 2 (macrophage); targeted mutation 1, Andreas Zimmer
MGI ID: MGI:2181023
Synonyms: CB2-, CB2tm1, CB2xP, CNR2-
Gene: Cnr2  Location: Chr4:135895394-135920207 bp, + strand  Genetic Position: Chr4, 68.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62417
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details341 nucleotides were deleted from the 3' end of the single exon and replaced with a neomycin selection cassette. The deleted region encoded a portion of the intracellular loop 3, transmembrane domains 6 and 7, and the C-terminus. Absence of ligand-binding in spleen sections and homogenates derived from homozygous mutant mice was determined by receptor autoradiography. In addition, binding studies of brain homogenates confirmed that the brain cannabinoid receptor was unaffected by the targeting event. (J:62417)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cnr2 Mutation:  8 strains or lines available
References
Original:  J:62417 Buckley NE, et al., Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur J Pharmacol. 2000 May 19;396(2-3):141-9
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory