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Targeted Allele Detail
Symbol: Prkacatm1Gsm
Name: protein kinase, cAMP dependent, catalytic, alpha; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2181021
Synonyms: Calpha-
Gene: Prkaca  Location: Chr8:83972993-83996443 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Neural tube defects leading to spina bifida in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77110
Parent Cell Line:  REK3 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6-8 were replaced with a neomycin resistance cassette via homologous recombination. The knockout allele was confirmed via the absence of protein product in brain of homozygous mutant animals as determined by Western blot analysis. (J:77110)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkaca Mutation:  14 strains or lines available
Original:  J:77110 Skalhegg BS, et al., Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol. 2002 Mar;16(3):630-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory