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Targeted Allele Detail
Symbol: Krt10tm1Tmm
Name: keratin 10; targeted mutation 1, Thomas M Magin
MGI ID: MGI:2180882
Gene: Krt10  Location: Chr11:99385254-99389364 bp, - strand  Genetic Position: Chr11, 62.92 cM
Krt10tm1Tmm/Krt10tm1Tmm mice show large areas of skin loss while Krt10tm1Tmm/Krt10+ mice show hyperkeratotic scaling of the skin

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:31853
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 7 were replaced by an HPRT cassette. Northern analysis showed a lack of transcript in homozygous mutant mice. (J:31853)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Krt10 Mutation:  20 strains or lines available
Original:  J:31853 Porter RM, et al., Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol. 1996 Mar;132(5):925-36
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory