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Targeted Allele Detail
Symbol: Sim2tm1Fan
Name: single-minded homolog 2 (Drosophila); targeted mutation 1, Chen-Ming Fan
MGI ID: MGI:2180881
Gene: Sim2  Location: Chr16:94085260-94127032 bp, + strand  Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
Germline Transmission:  Earliest citation of germline transmission: J:76787
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details422 bp of the 5' untranslated region and the first 144 bp of the gene coding region were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the first 48 amino acids of the basic helix-loop-helix domain. Gene expression is absent in kidneys from homozygous mutant animals as determined by in situ hybridization. (J:76787)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim2 Mutation:  7 strains or lines available
Original:  J:76787 Goshu E, et al., Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol. 2002 Jun;22(12):4147-57
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory