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Cebpdtm1Pfj
Targeted Allele Detail
Nomenclature
Symbol: Cebpdtm1Pfj
Name: CCAAT/enhancer binding protein (C/EBP), delta; targeted mutation 1, Peter F Johnson
MGI ID: MGI:2180841
Synonyms: C/EBPdelta-, C/EBPdelta-KO
Gene: Cebpd  Location: Chr16:15887286-15889545 bp, + strand  Genetic Position: Chr16, 10.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49799
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe single exon containing the entire coding region was replaced by a neomycin selection cassette. An absence of transcript in kidney and hippocampal tissue isolated from homozygous mutant mice was determined by Northern blot analysis. (J:49799)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpd Mutation:  4 strains or lines available
Notes
mRNA expression of Slc5a8 and Slc5a12 is undetectable in the kidneys of these mice, although expression appears normal in non-renal tissues (J:116932).
References
Original:  J:49799 Sterneck E, et al., Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10908-13
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory