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MaoaTg(H2-K1-Ifnb1)8Seif
Transgenic Allele Detail
Nomenclature
Symbol: MaoaTg(H2-K1-Ifnb1)8Seif
Name: monoamine oxidase A; transgene insertion 8, Isabelle Seif
MGI ID: MGI:2180818
Synonyms: MAO-A knockout, MAOA-KO, MaoaTg(H2-IFNB)8Seif, Tg8
Gene: Maoa  Location: ChrX:16619698-16687812 bp, + strand  Genetic Position: ChrX, 11.78 cM, cytoband A2
Transgene
origin
Strain of Origin:  C3H/HeOuJ
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsRandom integration of a transgene for IFN beta expressed under the control of a truncated H2-K1 promoter resulted in deletion of a 17 kb region encompassing exons 2 and 3 of the Maoa gene. Enzyme activity was absent in brain and spleen samples from mutant animals. (J:26232)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Maoa Mutation:  5 strains or lines available
References
Original:  J:26232 Cases O, et al., Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA [see comments]. Science. 1995 Jun 23;268(5218):1763-6
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory