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Targeted Allele Detail
Symbol: Cdc25ctm1Hpw
Name: cell division cycle 25C; targeted mutation 1, Helen Piwnica-Worms
MGI ID: MGI:2180791
Synonyms: Cdc25C-
Gene: Cdc25c  Location: Chr18:34866046-34884586 bp, - strand  Genetic Position: Chr18, 18.71 cM
Shortened villi in the small intestine of Cdc25atm1Hpw/Cdc25atm1.1Hpw Cdc25btm1Pjd/Cdc25btm1Pjd Cdc25ctm1Hpw/Cdc25ctm1Hpw Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ (TKO) mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69601
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was disrupted by the insertion of a neomycin resistance gene. Northern blot analysis of total testicular RNA showed the exclusive presence of a longer transcript, containing the neo transgene, in extracts from homozygous mutant mice. Western blot analysis of MEF lysates derived from homozygous mutant animals showed an absence of encoded protein using various antibodies. (J:69601)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc25c Mutation:  20 strains or lines available
Original:  J:69601 Chen MS, et al., Absence of apparent phenotype in mice lacking cdc25c protein phosphatase. Mol Cell Biol. 2001 Jun;21(12):3853-61
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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