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Ceacam1tm1Bcn
Targeted Allele Detail
Nomenclature
Symbol: Ceacam1tm1Bcn
Name: carcinoembryonic antigen-related cell adhesion molecule 1; targeted mutation 1, Nicole Beauchemin
MGI ID: MGI:2180785
Synonyms: Ceacam1aDelta4D, p
Gene: Ceacam1  Location: Chr7:25461707-25477603 bp, - strand  Genetic Position: Chr7, 13.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70815
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsAn allele with both hypo- and hypermorphic characteristics was generated by the insertion of a neomycin selection cassette in to intron 2. While the targeting vector was designed to incorporate engineered stop codons into exon 2 and thereby completely ablate expression of the four known isoforms, aberrant recombination resulted in the exclusion of the stop codons. Western blot analysis of various tissues showed low levels (less than 10% of wild-type) of the two D1-4 isoforms and increased levels of the two D1,4 isoforms that were double those of wild-type. (J:70815)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ceacam1 Mutation:  15 strains or lines available
References
Original:  J:70815 Blau DM, et al., Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection. J Virol. 2001 Sep;75(17):8173-86
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory