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Targeted Allele Detail
Symbol: Apoa1tm1Bres
Name: apolipoprotein A-I; targeted mutation 1, Jan L Breslow
MGI ID: MGI:2180783
Synonyms: A-I-deficient, apoA-I-deficient
Gene: Apoa1  Location: Chr9:46228580-46230466 bp, + strand  Genetic Position: Chr9, 25.36 cM, cytoband A2-A4
Germline Transmission:  Earliest citation of germline transmission: J:40819
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 and part of exon 4 were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis of liver from homozygous mutant animals using an exon 4 probe verified the absence of gene expression. (J:40819)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoa1 Mutation:  9 strains or lines available
Original:  J:40819 Plump AS, et al., ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res. 1997 May;38(5):1033-47
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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