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Cd69tm1Fsm
Targeted Allele Detail
Nomenclature
Symbol: Cd69tm1Fsm
Name: CD69 antigen; targeted mutation 1, Francisco Sanchez-Madrid
MGI ID: MGI:2180772
Synonyms: CD69 (-)
Gene: Cd69  Location: Chr6:129267325-129275436 bp, - strand  Genetic Position: Chr6, 63.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61329
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection gene was inserted to delete all of exons 2, 3, and 4, and the translated region of exon 5. Flow cytometric analysis of thymocytes stained with a monoclonal antibody revealed a lack of surface expression of the encoded protein in homozygous mutant mice. Additional analysis via flow cytometry showed an absence of protein expression in T cells derived from the kidney, spleen, and peripheral blood when activated with PMA. (J:61329)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd69 Mutation:  9 strains or lines available
References
Original:  J:61329 Lauzurica P, et al., Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood. 2000 Apr 1;95(7):2312-20
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory