About   Help   FAQ
Targeted Allele Detail
Symbol: Cd69tm1Fsm
Name: CD69 antigen; targeted mutation 1, Francisco Sanchez-Madrid
MGI ID: MGI:2180772
Synonyms: CD69 (-)
Gene: Cd69  Location: Chr6:129267324-129275375 bp, - strand  Genetic Position: Chr6, 63.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:61329
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection gene was inserted to delete all of exons 2, 3, and 4, and the translated region of exon 5. Flow cytometric analysis of thymocytes stained with a monoclonal antibody revealed a lack of surface expression of the encoded protein in homozygous mutant mice. Additional analysis via flow cytometry showed an absence of protein expression in T cells derived from the kidney, spleen, and peripheral blood when activated with PMA. (J:61329)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd69 Mutation:  1 strain or line available
Original:  J:61329 Lauzurica P, et al., Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood. 2000 Apr 1;95(7):2312-20
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory