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Del(9Cd3g-Cd3d)1Cpt
Targeted Allele Detail
Nomenclature
Symbol: Del(9Cd3g-Cd3d)1Cpt
Name: deletion, Chr 9, Cox Terhorst 1
MGI ID: MGI:2180768
Synonyms: Cd3d/Cd3gtm1Cpt, CD3gammadelta-
Gene: Del(9Cd3g-Cd3d)1Cpt  Location: unknown  Genetic Position: Chr9, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76991
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Del(9Cd3g-Cd3d)1Cpt involves 2 genes/genome features (Cd3g, Cd3d) View all
 
Mutation detailsThe adjacent Cd3d and the Cd3g loci are arranged in a head-to-head fashion enabling the targeting of exon 1 from each locus with a single hygromycin cassette. Northern analysis of thymocytes isolated from homozygous mice showed an absence of transcript from both loci. Expression of the related Cd3e and Cd3z genes was observed, though at levels above and below normal, respectively. (J:76991)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(9Cd3g-Cd3d)1Cpt Mutation:  0 strains or lines available
References
Original:  J:76991 Wang B, et al., Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytes. J Exp Med. 1998 Oct 5;188(7):1375-80
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory