Limk2^tm1Tnak
Targeted Allele Detail

Summary

• Symbol: Limk2^tm1Tnak
• Name: LIM domain kinase 2; targeted mutation 1, Toshikazu Nakamura
• MGI ID: MGI:2180766
• Synonyms: Limk2^flox
• Gene: Limk2 Location: Chr11:3294256-3359189 bp, - strand Genetic Position: Chr11, 2.34 cM
• Alliance: Limk2^tm1Tnak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73966
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A genomic region encompassing exons 3, 4, 5, and the testes-specific exon 1t, was flanked by a single loxP site in intron 2 and a floxed neo cassette in the intron between exon 1t and exon 6. (J:73966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Limk2 Mutation: 74 strains or lines available

References

• Original: J:73966 Takahashi H, et al., Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 gene. Dev Biol. 2002 Jan 15;241(2):259-72
• All: 1 reference(s)