Cd3d^tm1Kap
Targeted Allele Detail

Summary

• Symbol: Cd3d^tm1Kap
• Name: CD3 antigen, delta polypeptide; targeted mutation 1, Dietmar J Kappes
• MGI ID: MGI:2180760
• Synonyms: CD3delta-deficient, delta^-
• Gene: Cd3d Location: Chr9:44893067-44898350 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3d^tm1Kap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39925
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes most of the protein, was replaced with a neomycin selection cassette. RT-PCR and Northern blot analyses of homozygous mutant mice indicated an absence of normal transcript. Aberrant transcripts were reported. Normal levels of Cd3e and Cd3g transcript were detected. (J:39925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd3d Mutation: 26 strains or lines available

References

• Original: J:39925 Dave VP, et al., CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J. 1997 Mar 17;16(6):1360-70
• All: 10 reference(s)