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Targeted Allele Detail
Symbol: Cd34tm1Szk
Name: CD34 antigen; targeted mutation 1, Akira Suzuki
MGI ID: MGI:2180755
Gene: Cd34  Location: Chr1:194938819-194961279 bp, + strand  Genetic Position: Chr1, 98.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:32799
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of neomycin selection cassette deleted a 0.72-kb region including portions of exon 7 and exon 8 and encoding the entire transmembrane domain (amino acids 270 through 326). Staining of bone marrow cells isolated from homozygous mutant mice determined an absence of protein surface expression. Immunohistochemical staining and Western blot analysis confirmed a lack of protein in the lymph nodes of homozygous mutant mice. (J:32799)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd34 Mutation:  3 strains or lines available
Original:  J:32799 Suzuki A, et al., CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. Blood. 1996 May 1;87(9):3550-62
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory