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Pik3catm1Nbm
Targeted Allele Detail
Nomenclature
Symbol: Pik3catm1Nbm
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Robert L Nussbaum
MGI ID: MGI:2180704
Synonyms: p110alpha-, Pik3cadel
Gene: Pik3ca  Location: Chr3:32397671-32468486 bp, + strand  Genetic Position: Chr3, 15.7 cM, cytoband B
Hemorrhage is observed in Pik3catm1Nbm/Pik3catm1Nbm embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54237
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a PGK-neo cassette via homologous recombination resulting in deletion of the translation initiation site and the domain required for catalytic activity of the protein. (J:54237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ca Mutation:  18 strains or lines available
References
Original:  J:54237 Bi L, et al., Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem. 1999 Apr 16;274(16):10963-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory