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Cd22tm1Msn
Targeted Allele Detail
Nomenclature
Symbol: Cd22tm1Msn
Name: CD22 antigen; targeted mutation 1, Michael S Neuberger
MGI ID: MGI:2180701
Synonyms: CD22-
Gene: Cd22  Location: Chr7:30865404-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76974
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon encoding the transmembrane domain was replaced by a neomycin cassette. Flow cytometric analyis showed a lack of protein expression on the surface of splenic B cells isolated from homozygous mutant mice. (J:76974)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  38 strains or lines available
References
Original:  J:76974 O'Keefe TL, et al., Hyperresponsive B cells in CD22-deficient mice. Science. 1996 Nov 1;274(5288):798-801
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory