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Reltm1Hcl
Targeted Allele Detail
Nomenclature
Symbol: Reltm1Hcl
Name: reticuloendotheliosis oncogene; targeted mutation 1, Hsiou-Chi Liou
MGI ID: MGI:2180672
Synonyms: c-Rel-
Gene: Rel  Location: Chr11:23736847-23770970 bp, - strand  Genetic Position: Chr11, 14.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53513
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5 (which encodes amino acids 102-130) was replaced with a neomycin resistance gene via homologous recombination. Western blot assay of spleen lysates from homozygous mutant animals verified the absence of gene expression. (J:53513)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rel Mutation:  22 strains or lines available
References
Original:  J:53513 Liou HC, et al., c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol. 1999 Mar;11(3):361-71
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory