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Targeted Allele Detail
Symbol: Reltm1Hcl
Name: reticuloendotheliosis oncogene; targeted mutation 1, Hsiou-Chi Liou
MGI ID: MGI:2180672
Synonyms: c-Rel-
Gene: Rel  Location: Chr11:23736847-23770970 bp, - strand  Genetic Position: Chr11, 14.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:53513
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 (which encodes amino acids 102-130) was replaced with a neomycin resistance gene via homologous recombination. Western blot assay of spleen lysates from homozygous mutant animals verified the absence of gene expression. (J:53513)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rel Mutation:  24 strains or lines available
Original:  J:53513 Liou HC, et al., c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol. 1999 Mar;11(3):361-71
All:  35 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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