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Ccnd2tm1Wbg
Targeted Allele Detail
Nomenclature
Symbol: Ccnd2tm1Wbg
Name: cyclin D2; targeted mutation 1, Robert A Weinberg
MGI ID: MGI:2180642
Synonyms: CD2-, cyclin D2-, D2-
Gene: Ccnd2  Location: Chr6:127125162-127152188 bp, - strand  Genetic Position: Chr6, 61.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:37092
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette deleted exons 1 and 2. Protein was not detected in lysates from homozygous mutant embryos by Western blot analysis. (J:37092)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnd2 Mutation:  5 strains or lines available
References
Original:  J:37092 Sicinski P, et al., Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 5;384(6608):470-4
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory