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Targeted Allele Detail
Symbol: Cbltm1.1Hua
Name: Casitas B-lineage lymphoma; targeted mutation 1.1, Hua Gu
MGI ID: MGI:2180576
Synonyms: c-cbl-
Gene: Cbl  Location: Chr9:44142976-44234049 bp, - strand  Genetic Position: Chr9, 24.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:51666
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe transient expression of cre recombinase within ES cells resulted in the excision of a floxed region containing a neomycin gene and the exon containing nucleotides 681-837 of the published mouse cDNA sequence deposited in GenBank as X57111. The deletion introduced a frameshift mutation. RT-PCR analysis of total RNA extracts from homozygous mutant mice showed an absence of normal transcript. Western analysis using an antibody raised against the C-terminal failed to detect protein in homozygous mutant mice. (J:51666)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cbl Mutation:  19 strains or lines available
Original:  J:51666 Naramura M, et al., Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15547-52
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory