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Tg(Ckmm-Cav3)1Ysu
Transgene Detail
Nomenclature
Symbol: Tg(Ckmm-Cav3)1Ysu
Name: transgene insertion 1, Yoshihide Sunada
MGI ID: MGI:2180562
Synonyms: CAV-3P104L, mCAV-3Tg, TgCAV3M1
Transgene: Tg(Ckmm-Cav3)1Ysu  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/Slc x DBA/Slc)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckmm-Cav3)1Ysu expresses 1 gene
 
Mutation detailsSequence encoding Cav3 modified to contain proline to leucine missense mutation at codon 104 was adjoined to a 6.5-kb fragment of the Ckmm promoter region. Expression of the transgene and endogenous Cav3 gene were confirmed by Northern blot and RT-PCR analyses, respectively. (J:67174)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:67174 Sunada Y, et al., Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity. Hum Mol Genet. 2001 Feb 1;10(3):173-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory