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Mtrtm1Lcb
Targeted Allele Detail
Nomenclature
Symbol: Mtrtm1Lcb
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase; targeted mutation 1, Lawrence C Brody
MGI ID: MGI:2180496
Synonyms: MS-, Mtr-
Gene: Mtr  Location: Chr13:12182712-12258113 bp, - strand  Genetic Position: Chr13, 4.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67384
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA PGK-neo cassette was inserted to delete a region spanning from the middle of exon 3 through exon 6. This deleted region encodes the essential homocysteine binding domain. Reduced levels of transcript were observed in extracts from the liver and kidney of heterozygous mutant mice. Enzyme activity levels in heterozygotes were found to be approximately 60% of wild-type. (J:67384)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 16 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtr Mutation:  6 strains or lines available
References
Original:  J:67384 Swanson DA, et al., Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol. 2001 Feb;21(4):1058-65
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory