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Targeted Allele Detail
Symbol: Dlx5tm1Levi
Name: distal-less homeobox 5; targeted mutation 1, Giovanni Levi
MGI ID: MGI:2180474
Synonyms: Dlx5-lacZ, Dlx5/LacZ
Gene: Dlx5  Location: Chr6:6877805-6882085 bp, - strand  Genetic Position: Chr6, 2.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:56557
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector containg a promoterless lacZ gene and a floxed neomycin resistance gene under the control of a RSV promoter was used to delete a region spanning from within exon 1 to the 5' region of exon 3. RT-PCR analysis showed an absence of transcript in total RNA obtained from homozygous mutant embryos. This allele was used to generate a subsequent allele, Dlx5tm1.1Levi, which lacks the neomycin resistance gene. (J:56557)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 49 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlx5 Mutation:  11 strains or lines available
Original:  J:56557 Acampora D, et al., Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory