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Tfap2btm1Rbu
Targeted Allele Detail
Nomenclature
Symbol: Tfap2btm1Rbu
Name: transcription factor AP-2 beta; targeted mutation 1, Reinhard Buettner
MGI ID: MGI:2180473
Synonyms: AP-2Beta-, Tcfap2btm1Rbu
Gene: Tfap2b  Location: Chr1:19208914-19238576 bp, + strand  Genetic Position: Chr1, 6.19 cM, cytoband A2-A4
Postaxial accessory digits in Tfap2btm1Rbu/Tfap2btm1Rbu mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42260
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a PGK-neo cassette disrupted exon 4, which encodes an essential DNA binding domain. Northern blot and Western blot analyses showed an absence of transcript and protein, respectively, in midbrain lysates obtained from homozygous mutant mice. (J:42260)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfap2b Mutation:  2 strains or lines available
References
Original:  J:42260 Moser M, et al., Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 Aug 1;11(15):1938-48
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory