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Targeted Allele Detail
Symbol: Sim1tm1Fan
Name: single-minded family bHLH transcription factor 1; targeted mutation 1, Chen-Ming Fan
MGI ID: MGI:2180390
Synonyms: Sim-
Gene: Sim1  Location: Chr10:50894754-50989152 bp, + strand  Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
Germline Transmission:  Earliest citation of germline transmission: J:50772
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette was inserted to replace the first 750 nucleotides of the 5' region, the initiation codon, and the first 17 codons of the basic helix-loop-helix (bHLH) domain. While message was present in homozygous mutant mice at levels only slightly below normal, immunocytochemistry analysis showed an absence of protein product in the coronal sections of the brain. (J:50772)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sim1 Mutation:  32 strains or lines available
Original:  J:50772 Michaud JL, et al., Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 1998 Oct 15;12(20):3264-75
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory