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Asgr1tm1Ishi
Targeted Allele Detail
Nomenclature
Symbol: Asgr1tm1Ishi
Name: asialoglycoprotein receptor 1; targeted mutation 1, Shun Ishibashi
MGI ID: MGI:2180369
Synonyms: MHL-1 -
Gene: Asgr1  Location: Chr11:70054085-70057894 bp, + strand  Genetic Position: Chr11, 42.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68876
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene under the control of a pol2 promoter replaced the transcription initiation codon and the sequences encoding the transmembrane domain. Northern blot analysis showed an absence of normal transcipt in homozygous mutant mice. A truncated message was detected, however, Western blot analysis showed there to be no protein expression in homozygous mutant animals. (J:68876)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asgr1 Mutation:  10 strains or lines available
References
Original:  J:68876 Tozawa R, et al., Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor. J Biol Chem. 2001 Apr 20;276(16):12624-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory