Arg2^tm1Weo
Targeted Allele Detail

Summary

• Symbol: Arg2^tm1Weo
• Name: arginase type II; targeted mutation 1, William E O'Brien
• MGI ID: MGI:2180319
• Synonyms: argII^mut
• Gene: Arg2 Location: Chr12:79177562-79203075 bp, + strand Genetic Position: Chr12, 35.51 cM
• Alliance: Arg2^tm1Weo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene under the control of an RNA polymerase II promoter replaced portions of exons 4 and 5. The insertion resulted in a frameshift that ablated the enzymatic activity of the protein product in the kidneys of homozygous mutant mice. The enzymatic activity was higher than expected in heterozygous animals but the authors noted a large statistical variation. (J:67353)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arg2 Mutation: 14 strains or lines available

References

• Original: J:67353 Shi O, et al., Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol. 2001 Feb;21(3):811-3
• All: 38 reference(s)