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Arg2tm1Weo
Targeted Allele Detail
Nomenclature
Symbol: Arg2tm1Weo
Name: arginase type II; targeted mutation 1, William E O'Brien
MGI ID: MGI:2180319
Synonyms: argIImut
Gene: Arg2  Location: Chr12:79130788-79156301 bp, + strand  Genetic Position: Chr12, 35.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67353
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene under the control of an RNA polymerase II promoter replaced portions of exons 4 and 5. The insertion resulted in a frameshift that ablated the enzymatic activity of the protein product in the kidneys of homozygous mutant mice. The enzymatic activity was higher than expected in heterozygous animals but the authors noted a large statistical variation. (J:67353)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arg2 Mutation:  10 strains or lines available
References
Original:  J:67353 Shi O, et al., Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene. Mol Cell Biol. 2001 Feb;21(3):811-3
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory