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Nfkb2tm2Brv
Targeted Allele Detail
Nomenclature
Symbol: Nfkb2tm2Brv
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 2, Rodrigo Bravo
MGI ID: MGI:2180306
Synonyms: Nfkappab2-, NF-kappaB2-, NF-kappaB2 KO, p100, p52
Gene: Nfkb2  Location: Chr19:46304737-46312090 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76380
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by the replacement of exon 4 with a neomycin resistance cassette via homologous recombination. Radioimmunoprecipitation assay and electrophoretic mobility shift assay (EMSA) did not detect any protein product in thymus and spleen extracts from homozygous mutant animals. (J:76380)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:  21 strains or lines available
References
Original:  J:76380 Caamano JH, et al., Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med. 1998 Jan 19;187(2):185-96
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory