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Tnfsf14tm1Lpc
Targeted Allele Detail
Nomenclature
Symbol: Tnfsf14tm1Lpc
Name: tumor necrosis factor (ligand) superfamily, member 14; targeted mutation 1, Lieping Chen
MGI ID: MGI:2180198
Synonyms: LIGHT-, LIGHTnull
Gene: Tnfsf14  Location: Chr17:57189492-57194189 bp, - strand  Genetic Position: Chr17, 29.71 cM, cytoband D-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76414
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant mice was confirmed via RT-PCR analysis of spleen cell RNA. (J:76414)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf14 Mutation:  16 strains or lines available
References
Original:  J:76414 Tamada K, et al., Cutting Edge: Selective Impairment of CD8(+) T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT. J Immunol. 2002 May 15;168(10):4832-5
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory