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Ccl5tm1Hso
Targeted Allele Detail
Nomenclature
Symbol: Ccl5tm1Hso
Name: chemokine (C-C motif) ligand 5; targeted mutation 1, Hiroshi Sato
MGI ID: MGI:2180195
Synonyms: CCL5-KO, RANTES-
Gene: Ccl5  Location: Chr11:83525778-83530518 bp, - strand  Genetic Position: Chr11, 50.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75842
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 333 bp region of the gene containing the promoter, transcription and translation initiation sites, and part of exon 1 was replaced with a PGK-hygro cassette via homologous recombination. Northern blot analysis confirmed the absence of gene expression in homozygous mutant mice. (J:75842)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl5 Mutation:  4 strains or lines available
References
Original:  J:75842 Makino Y, et al., Impaired T cell function in RANTES-deficient mice. Clin Immunol. 2002 Mar;102(3):302-9
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory