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Targeted Allele Detail
Symbol: Tbx21tm1Glm
Name: T-box 21; targeted mutation 1, Laurie H Glimcher
MGI ID: MGI:2180194
Synonyms: T-bet-, Tbx21-
Gene: Tbx21  Location: Chr11:97098071-97115331 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Phenotype of aortic arch atherosclerotic lesions in Tbx21tm1Glm/Tbx21tm1Glm Ldlrtm1Her/Ldlrtm1Her and Ldlrtm1Her/Ldlrtm1Her mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:73833
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was used to replace a 2 kb region containing exon 1 and its flanking sequence. An absence of mRNA and protein were observed in T cells isolated from the lymph nodes of homozygous mutant mice by Northern blot and Western blot analysis, respectively. (J:73833, J:96620)
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:  16 strains or lines available
Phenotypic Similarity to Human Syndrome: Susceptibility to Spontaneous Ulcerative Colitis (Rag2tm1Fwa Tbx21tm1Glm double homozygotes J:141481)

Original:  J:73833 Szabo SJ, et al., Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002 Jan 11;295(5553):338-42
All:  190 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory