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Targeted Allele Detail
Symbol: Cacna1btm1Ksw
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Kohei Sawada
MGI ID: MGI:2180187
Synonyms: alpha-, alpha1B-, Cav2.2-
Gene: Cacna1b  Location: Chr2:24603887-24763152 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:76458
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe exon encoding the central portion of the cytoplasmic repeat II-III linker was disrupted by insertion of a PGK-neo cassette via homologous recombination. RT-PCR analysis verified the presence of mutant transcripts in brain of homozygous mutant animals. (J:76458)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:  5 strains or lines available
Original:  J:76458 Ino M, et al., Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5323-8
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory