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Targeted Allele Detail
Symbol: Araftm1Mmc
Name: Araf proto-oncogene, serine/threonine kinase; targeted mutation 1, Martin McMahon
MGI ID: MGI:2180180
Synonyms: X-
Gene: Araf  Location: ChrX:20797814-20860519 bp, + strand  Genetic Position: ChrX, 16.3 cM, cytoband A2-A3.1
Germline Transmission:  Earliest citation of germline transmission: J:33951
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a region encoding the cysteine finger of the CR1 domain, the entire CR2 domain, and the ATP-binding site of the CR3 domain. Western blot analysis of embryonic fibroblasts derived from hemizygous mice indicated an absence of protein encoded by the targeted locis and showed normal levels of protein produced by an adjacent locus. (J:33951)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Araf Mutation:  23 strains or lines available
Original:  J:33951 Pritchard CA, et al., Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene. Curr Biol. 1996 May 1;6(5):614-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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