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Targeted Allele Detail
Symbol: Stambptm1Sug
Name: STAM binding protein; targeted mutation 1, Kazuo Sugamura
MGI ID: MGI:2180168
Synonyms: AMSH-/-
Gene: Stambp  Location: Chr6:83543211-83572729 bp, - strand  Genetic Position: Chr6, 35.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:72940
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA single loxP site was inserted 5' to exon 3 and a neomycin selection cassette followed by a loxP site was inserted 3' to exon 4 through homologous recombination. The transient expression of Cre-recombinase within the targeted ES cells resulted in the excision of exons 3 and 4 and the neomycin selection gene. Northern blot analysis of total RNA isolated from the brains of homozygous animals demonstrated that no detectable transcript was expressed from this allele. (J:72940)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stambp Mutation:  3 strains or lines available
Original:  J:72940 Ishii N, et al., Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficient Mice. Mol Cell Biol. 2001 Dec;21(24):8626-37
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
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