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Targeted Allele Detail
Symbol: Adora1tm1Bbf
Name: adenosine A1 receptor; targeted mutation 1, Bertil B Fredholm
MGI ID: MGI:2180136
Synonyms: A1AR-, A1-KO, A1R-
Gene: Adora1  Location: Chr1:134199223-134235431 bp, - strand  Genetic Position: Chr1, 58.15 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:70664
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced most of the coding region and a portion of the of the 3' flanking region of the targeted exon. An absence of the normal protein was observed using in situ hybridization and autoradiographic analysis using a labeled ligand, DPCPX. (J:70664)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora1 Mutation:  1 strain or line available
Original:  J:70664 Johansson B, et al., Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9407-12
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory