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Grk2tm1Mca
Targeted Allele Detail
Nomenclature
Symbol: Grk2tm1Mca
Name: G protein-coupled receptor kinase 2; targeted mutation 1, Marc Caron
MGI ID: MGI:2180127
Synonyms: betaARK1-, GRK2-
Gene: Grk2  Location: Chr19:4286001-4306222 bp, - strand  Genetic Position: Chr19, 3.98 cM
Cardiac abnormalities in Grk2tm1Mca/Grk2tm1Mca mouse embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36567
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exons 5 through 8, encoding catalytic subdomain I that contains a portion of an ATP-binding site. The insertion also altered the downstream reading frame. Northern blot analysis of mutant embryos showed a 62% reduction of transcripts in heterozygotes and an absence of transcripts in homozygotes. Western blot analysis showed correlative results. (J:36567)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk2 Mutation:  22 strains or lines available
References
Original:  J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory