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Targeted Allele Detail
Symbol: Asic2tm1Wsh
Name: acid-sensing (proton-gated) ion channel 2; targeted mutation 1, Michael J Welsh
MGI ID: MGI:2180111
Synonyms: ASIC2-, BNC1-
Gene: Asic2  Location: Chr11:80880169-81968457 bp, - strand  Genetic Position: Chr11, 48.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:76712
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted to disrupt two exons encoding the second transmembrane domain, which is common to both splice variants, as well as a channel pore. Transcripts were not detected in the brains of homozygous mutant mice. Neither in situ hybridization nor immunostaining detected protein in the large or small dorsal root ganglion neurons of homozygous animals. (J:76712)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Asic2 Mutation:  19 strains or lines available
Original:  J:76712 Price MP, et al., The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 2000 Oct 26;407(6807):1007-11
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory