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Targeted Allele Detail
Symbol: Adh7tm1Gdu
Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; targeted mutation 1, Gregg Duester
MGI ID: MGI:2180102
Synonyms: Adh4-
Gene: Adh7  Location: Chr3:138217760-138233382 bp, + strand  Genetic Position: Chr3, 64.13 cM
Germline Transmission:  Earliest citation of germline transmission: J:56168
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced the promoter and exons 1 through 6. Northern blot analysis showed an absence of transcript in extracts isolated from the stomach and skin tissue of homozygous mutant mice. Western blot analysis confirmed a lack of encoded protein and normal levels of other alcohol dehydrogenases in homozygous mutant animals. (J:56168)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adh7 Mutation:  2 strains or lines available
Original:  J:56168 Deltour L, et al., Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. Dev Genet. 1999;25(1):1-10
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory