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Adh5tm1Gdu
Targeted Allele Detail
Nomenclature
Symbol: Adh5tm1Gdu
Name: alcohol dehydrogenase 5 (class III), chi polypeptide; targeted mutation 1, Gregg Duester
MGI ID: MGI:2180101
Synonyms: Adh3-
Gene: Adh5  Location: Chr3:138443093-138455499 bp, + strand  Genetic Position: Chr3, 64.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55555
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing a PGK-neo gene upstream of exon 5 was used to replace exons 1 through 4. Transcripts were undetectable in total RNA extracts from the liver, kidney, and epididymis of homozygous mutant mice by Northern blot analysis. A lack of protein expression was confirmed by Western blot analysis. (J:55555)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adh5 Mutation:  12 strains or lines available
References
Original:  J:55555 Deltour L, et al., Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice. Overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid. J Biol Chem. 1999 Jun 11;274(24):16796-801
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory