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Adcyap1r1tm1Bbt
Targeted Allele Detail
Nomenclature
Symbol: Adcyap1r1tm1Bbt
Name: adenylate cyclase activating polypeptide 1 receptor 1; targeted mutation 1, Philippe Brabet
MGI ID: MGI:2180097
Synonyms: PAC1-
Gene: Adcyap1r1  Location: Chr6:55451978-55501451 bp, + strand  Genetic Position: Chr6, 27.38 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62115
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a 2.3-kb fragment containing exons 8 through 11. The neo gene was situated in the reverse transcriptional orientation and was excised during the splicing of the transcript, resulting in a frameshift that introduces a stop codon in exon 12. A truncated transcript was observed by RT-PCR analysis. A 90% decrease in binding of a radio-labeled ligand in homozygous mutants was observed versus wild-type, as well as an absence of cAMP production stimulation. (J:62115)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1r1 Mutation:  17 strains or lines available
References
Original:  J:62115 Jamen F, et al., PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance. J Clin Invest. 2000 May;105(9):1307-15
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory