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Nr5a1tm2.1Klp
Targeted Allele Detail
Nomenclature
Symbol: Nr5a1tm2.1Klp
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 2.1, Keith L Parker
MGI ID: MGI:2180092
Synonyms: R
Gene: Nr5a1  Location: Chr2:38692656-38714542 bp, - strand  Genetic Position: Chr2, 24.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66593
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis heritable allele is a derivative of Nr5a1tm2Klp in which the loxP-flanked sequences were deleted by ectopic Cre recombinase activity in germ cells. (J:66593)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr5a1 Mutation:  16 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hypogonadotropic Hypogonadism in mice heterozygous for Nr5a1tm2Klp and Nr5a1tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (J:66593)
References
Original:  J:66593 Zhao L, et al., Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001 Jan;128(2):147-54
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory