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Targeted Allele Detail
Symbol: Acrtm1Tba
Name: acrosin prepropeptide; targeted mutation 1, Tadashi Baba
MGI ID: MGI:2180087
Gene: Acr  Location: Chr15:89568326-89574585 bp, + strand  Genetic Position: Chr15, 44.96 cM, cytoband E-F
Germline Transmission:  Earliest citation of germline transmission: J:21944
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was used to replace a portion of exon 2 and all of exon 3. The deleted region encoded His70 and Asp124, which are required for serine protease activity, as well as 5 Cys residues involved in disulfide bonds. Northern analysis using a cDNA fragment containing exons 2 and 3 showed an absence of mRNA in extracts isolated from the testes of homozygous mutant mice. Protease activity in cauda epididymal sperm was assayed and found to be absent in homozygous animals. (J:21944)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acr Mutation:  1 strain or line available
Original:  J:21944 Baba T, et al., Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization. J Biol Chem. 1994 Dec 16;269(50):31845-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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