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Acp2tm1Psa
Targeted Allele Detail
Summary
Symbol: Acp2tm1Psa
Name: acid phosphatase 2, lysosomal; targeted mutation 1, Paul Saftig
MGI ID: MGI:2180084
Synonyms: LAP-
Gene: Acp2  Location: Chr2:91033230-91044443 bp, + strand  Genetic Position: Chr2, 50.54 cM
Alliance: Acp2tm1Psa page
Acp2tm1Psa/Acp2tm1Psa mice develop lower thoracic kyphosis and upper thoracic lordosis with age

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41986
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted into exon 7, introducing a translational stop codon into the open reading frame. Northern blot analysis showed an absence of expression in the livers and kidneys of homozygous mice. No enzymatic activity was detected in assays of kidney and spleen homogenates from homozygotes. (J:41986)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acp2 Mutation:  27 strains or lines available
References
Original:  J:41986 Saftig P, et al., Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system. J Biol Chem. 1997 Jul 25;272(30):18628-35
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory