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Acadvltm1Uab
Targeted Allele Detail
Nomenclature
Symbol: Acadvltm1Uab
Name: acyl-Coenzyme A dehydrogenase, very long chain; targeted mutation 1, University of Alabama
MGI ID: MGI:2180080
Synonyms: VLCAD-
Gene: Acadvl  Location: Chr11:70010183-70015411 bp, - strand  Genetic Position: Chr11, 42.96 cM, cytoband B2-B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72193
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette was used to replace exons 7 through 19 and the first 33 nucleotides of exon 20. Western analysis of the livers of homozygous mutant mice showed an absence of protein. (J:72193)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acadvl Mutation:  14 strains or lines available
References
Original:  J:72193 Cox KB, et al., Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. Hum Mol Genet. 2001 Sep 15;10(19):2069-77
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory