Actc1tm1Jll
Targeted Allele Detail
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Symbol: |
Actc1tm1Jll |
Name: |
actin, alpha, cardiac muscle 1; targeted mutation 1, James Lessard |
MGI ID: |
MGI:2180072 |
Synonyms: |
cardiac alpha-actin- |
Gene: |
Actc1 Location: Chr2:113877763-113883356 bp, - strand Genetic Position: Chr2, 57.55 cM
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Alliance: |
Actc1tm1Jll page
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Myofibrillar disarray in newborn Actc1tm1Jll/Actc1tm1Jll hearts
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:40165
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A targeting construct containing HPRT was used to disrupt exon 2. A truncated transcript was detected in extracts from the hearts of homozygous mutant mice, but was shown to be non-coding by the lack of either a normal or truncated peptide in Western blots.
(J:40165)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Actc1 Mutation: |
24 strains or lines available
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Original: |
J:40165 Kumar A, et al., Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4406-11 |
All: |
3 reference(s) |
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