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Nr5a1tm2Klp
Targeted Allele Detail
Nomenclature
Symbol: Nr5a1tm2Klp
Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 2, Keith L Parker
MGI ID: MGI:2180013
Synonyms: F, Sf1Fl
Gene: Nr5a1  Location: Chr2:38692656-38714542 bp, - strand  Genetic Position: Chr2, 24.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66593
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted into an intron 5' to the last coding exon, and a loxP site followed by a neomycin resistance cassette was inserted 3' to this exon. This mutation flanks sequences encoding motifs essential for transcriptional activity as well as the transcription termination and polyadenyulation sequences. (J:66593)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr5a1 Mutation:  11 strains or lines available
References
Original:  J:66593 Zhao L, et al., Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 2001 Jan;128(2):147-54
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory